Here is a comprehensive summary of the Wikipedia article about "House":
House (also known as House, M.D.) was an acclaimed American medical drama created by David Shore, airing on Fox from November 16, 2004, to May 21, 2012, for eight seasons. The series starred Hugh Laurie as Dr. Gregory House, a brilliant yet misanthropic and cynical medical genius who, despite his dependence on pain medication, led a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital. House's unconventional methods and disregard for rules often put him at odds with hospital administrator Dr. Lisa Cuddy and his various diagnostic teams, though he shared a complex friendship with Dr. James Wilson.
Conceived by Paul Attanasio and developed by Shore, the character of Dr. House was loosely inspired by Arthur Conan Doyle's Sherlock Holmes, with the show itself pitched as a "medical detective program." Globally popular, particularly in 2008 when it was the world's most-watched TV program, the series garnered numerous accolades, including five Primetime Emmy Awards and two Golden Globe Awards, before concluding after its eighth season.